A case control study of hsCRP as a marker in assessing severity of asthma
Are Suryakari Sreekanth, P Ajoy Kumar
Introduction: In asthma, not only local but also systemic inflammation occurs and hs-CRP may play a role in the pathogenesis of asthma. The C-reactive protein (CRP) its capacity to precipitate the somatic C-polysaccharide of Streptococcus pneumoniae is an exquisitely sensitive non-specific marker of acute inflammation and tissue damageMaterial and Methods: This is prospective and descriptive study patients were conducted among patients with asthma presented for follow -up examination in outpatient Department of Pulmonary Medicine, Kurnool Medical College from January 2018 to December 2018. The patients were on maintenance treatment including inhaled corticosteroids and bronchodilators according to the guideline treatment of asthma. Result: In our present study, a total of 75 patients were included, most of the patients were 51-70 years i.e., 39 out of 75 (52.0%), followed by 31-50 years, i.e., 26 out of 75 (34.6%) in case group. On the other hand, 38 out of 75 (50.6%) followed by 29 out of 75 (38.6%) in control group. The mean hs CRP of Case group patients are 3.83±0.92 mg/L and in control group patients 0.77±0.23 mg/L. Pulmonary function test using Spirometer was s done in all the patients (case and control). The FEV1 values are compared against hsCRP values. Statistical significance is assessed using Spearmann’s correlation. Case group patients showing highly significant negative correlation of hsCRP with FEV1.Conclusion: The results of this study indicated increased serum hsCRP concentration in asthma compared to controls. Increased serum hs-CRP correlates positively with severity of asthma and thus can be considered as a tool in predicting asthma status.
Are Suryakari Sreekanth, P Ajoy Kumar. A case control study of hsCRP as a marker in assessing severity of asthma. International Journal of Pulmonary and Respiratory Research, Volume 2, Issue 1, 2020, Pages 08-10